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Interactions between cannabidiol and commonly used antiepileptic drugs. Trial of cannabidiol for drug-resistant seizures in the Dravet Syndrome. Labeling accuracy of cannabidiol extracts sold online.

JAMA Nov; The non-psychoactive cannabis-constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis.

Analgesic and anti-inflammatory activity of constituents of Cannabis sativa L. Inflammation ; Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania.

J Psychopharmacol ; Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression.

Br J Pharmacol ; Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement.

Neurosci Lett ; Cannabidiol: a promising new drug for neurodegenerative disorders? CNS Neurosci Ther ; Bisogno T, Di Marzo Y.

The role of the endocannabinoid system in Alzheimer's disease: facts and hypotheses. Curr Pharm Des ; Zuardi AW. Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action.

Rev Bras Psiquiatr ; Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Trends Pharmacol Sci ; Booz GW. Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress.

Free Radic Biol Med ; Pickens JT. Sedative activity of cannabis in relation to its delta'-trans-tetrahydrocannabinol and cannabidiol content.

Monti JM. Hypnoticlike effects of cannabidiol in the rat. Psychopharmacology Berl ; Karler R, Turkanis SA. Subacute cannabinoid treatment: anticonvulsant activity and withdrawal excitability in mice.

The anticonvulsant activity of cannabidiol and cannabinol. Life Sci ; Anticonvulsant interaction of cannabidiol and ethosuximide in rats.

J Pharm Pharmacol ; Consroe P, Wolkin A. Cannabidiol-antiepilpetic drug comparisons and interactions in experimentally induced seizures in rats.

J Pharmacol Exp Ther ; Letter: Cannabidiol and Cannabis sativa extract protect mice and rats against convulsive agents.

Assessing antidepressant activity in rodents: recent developments and future needs. Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L.

Pharmacol Biochem Behav ; Effects of intracisternal administration of cannabidiol on the cardiovascular and behavioral responses to acute restraint stress.

Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats. FEBS Lett ; Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis.

PLoS One ;6:e Modulation of mediotemporal and ventrostriatal function in humans by Delta9-tetrahydrocannabinol: a neural basis for the effects of Cannabis sativa on learning and psychosis.

Arch Gen Psychiatry ; Influence of cannabidiol on deltatetrahydrocannabinol effects. Clin Pharmacol Ther ; Cannabidiol increases Fos expression in the nucleus accumbens but not in the dorsal striatum.

Cannabidiol inhibits the hyperlocomotion induced by psychomimetic drugs in mice. Eur J Pharmacol ; Int J Neuropsychopharmacol ; Effects of cannabidiol in animal models predictive of antipsychotic activity.

Cannabidiol reverses the reduction in social interaction produced by low dose Delta-tetrahydrocannabinol in rats. Cannabidiol as a potential treatment for psychosis.

Eur Neuropsychopharmacol ; Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders.

Modulation of effective connectivity during emotional processing by Delta 9-tetrahydrocannabinol and cannabidiol. Cannabidiol inhibitory effect on marble-burying behavior: involvement of CB1 receptors.

Behav Pharmacol ; Anti-aversive effects of cannabidiol on innate fear-induced behaviors evoked by an ethological model of panic attacks based on a prey vs the wild snake Epicrates cenchria crassus confrontation paradigm.

Neuropsychopharmacology ; Behav Pharmacol ;S Effects of cannabidiol and diazepam on behavioral and cardiovascular responses induced by contextual conditioned fear in rats.

Behav Brain Res ; Anxiolytic-like effect of cannabidiol in the rat Vogel conflict test. Prog Neuropsychopharmacol Biol Psychiatry ; Pharmacological characterization of cannabinoids in the elevated plus maze.

Antianxiety effect of cannabidiol in the elevated plus-maze. Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation.

J Hepatol ; Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy.

J Am Coll Cardiol ; Cannabidiol protects retinal neurons by preserving glutamine synthetase activity in diabetes. Mol Vis ; Neuroprotective and blood-retinal barrier-preserving effects of cannabidiol in experimental diabetes.

Am J Pathol ; Cannabidiol attenuates high glucose-induces endothelial cell inflammatory response and barrier disruption.

Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type 1 diabetic peripheral neuropathic pain.

Mol Pain ; Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer. J Mol Med Berl ; A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells.

Int Immunopharmacol ; J Neurochem ; Cannabidiol, a non-psychoactive cannabinoid compound inhibits human glioma cell migration and invasiveness.

A combined preclinical therapy of cannabinoids and temozolomide against glioma. Mol Cancer Ther ; Serum-dependent effects of tamoxifen and cannabinoids upon C6 glioma cell viability.

Biochem Pharmacol ; Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy.

Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis. Breast Cancer Res Treat ; Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells.

Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma. Cannabidiol as a potential anticancer drug.

Br J Clin Pharmacol ; Cannabis with high cannabidiol content is associated with fewer psychotic experiences.

Schizophr Res ; Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment.

Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders.

Epilepsia ; Sativex long-term use: an open-label trial in patients with spasticity due to multiple sclerosis. J Neurol ; A placebo-controlled, parallel group, randomized withdrawal study of subjects with symptoms of spasticity due to multiple sclerosis who are receiving long-term Sativex nabiximols.

Mult Scler ; An open-label study of cannabis-based extracts for bladder dysfuntion in advanced multiple sclerosis. Randomized controlled trial of Sativex to treat detrusor overactivity in multiple sclerosis.

Long-term use of a cannabis-based treatment in spasticity and other symptoms in multiple sclerosis. Eur J Neurol ; GW Pharmaceuticals Web site.

Accessed: May 31, Natural Medicines Web site. Accessed May 31, Effects of ipsapirone and cannabidiol on human experimental anxiety.

J Psychopharmacol ;7 1 Suppl Long-retained metabolites of delta9- and delta8-tetrahydrocannabinols identified as novel fatty acid conjugates.

Res Commun Chem Pathol Pharmacol ; Pharmacokinetics of cannabidiol in dogs. Drug Metab Dispos ; In vivo cytogenetic effects of cannabinoids.

J Clin Psychopharmacol ; Early cannabinoid exposure influences neuroendocrine and reproductive functions in mice: II. Postnatal effects.

Toxicity of short-term administration of cannabinoids to rhesus monkeys. Toxicol Appl Pharmacol ; Open label evaluation of cannabidiol in dystonic movement disorders.

Int J Neurosci ; Neural basis of anxiolytic effects of cannabidiol CBD in generalized social anxiety disorder: a preliminary report.

Cannabidiol was ineffective for manic episode of bipolar affective disorder. Cannabidiol monotherapy for treatment-resistant schizophrenia.

Characterization of cannabidiol-mediated cytochrome P inactivation. Harvey DJ. Absorption, distribution, and biotransformation of the cannabinoids.

Marijuana and Medicine. Potent inhibition of human cytochrome P 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety.

Life Sci ;88 Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Differential inhibition of human cytochrome P 2A6 and 2B6 by major phytocannabinoids.

Forensic Toxicol ; Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective potent inhibitors of human CYP1 enzymes.

Cannabidiol for the treatment of psychosis in Parkinson's disease. Antipsychotic effect of cannabidiol.

J Clin Psychiatry ; Cannabidiol reduces cigarette consumption in tobacco smokers: preliminary findings. Addict Behav ; Pertwee RG. The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delat9-tetrahydrocannabivarin.

The efficacy of cannabidiol in the treatment of schizophrenia - a translational approach. Schizophr Bull ;37 Suppl 1 Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia.

Transl Psychiatry ;2:e Cannabis for dyskinesia in Parkinson disease: a randomized double-blind crossover study.

Neurology ; Cannabidiol: an overview of some pharmacological aspects. Its legal status in countries is something for national legislators to decide.

Some countries have eased regulations around cannabidiol, to consider products containing CBD to be medical products.

WHO does not recommend cannabidiol for medical use. Initial evidence from animal and human studies i. Some people have been using cannabidiol to calm spasms during epileptic fits.

CBD For Cancer. CBD For Depression. CBD For Epilepsy. CBD For Glaucoma. CBD For Inflammation. CBD For Nausea. CBD For Neuro-degeneration.

CBD For Neuropathy. CBD For Obesity. CBD For Rheumatism. CBD For Schizophrenia. CBD For Sleep.

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Most states have detailed information relating to the legal status of recreational cannabis, CBD, and what is increasingly referred to as 'medicinal cannabis'.

In Irishman William Brooke O'Shaughnessy introduced cannabis extract to American pharmacies and thus began it's popularity as a remedy.

A wide range of cannabis extracts became freely available and could be gotten from travelling doctors, 'snake oil salesmen', and apothecaries across America and Europe.

The general lack of controls and regulation at the time lead to some deaths and injuries linked back to supposed cannabis extracts.

Unscrupulous makers produced formulations that were of questionable quality for quick profits and some cases the ingredients were toxic or poisonous.

This unfortunate practice was widespread across the profitable field of medicine and remedies. The new regulations, however, did nothing to stem criticism about the availability of narcotics in particular and around there was a new round of legislation aimed to strengthen requirements for their sale and remove 'loopholes' in poison laws.

The revisions were designed to restrict all narcotics, including cannabis, as poisons therefore requiring a doctors prescription and limiting sales to pharmacies only.

The act was again updated in to the Federal Pure Food, Drug, and Cosmetics Act of which is still current as of the early 21st century.

To date, marijuana remains under this law defined as a "dangerous drug". CBD as a separate substance or as an ingredient of other products is legal across the USA since it is a hemp extract however when purchasing people should check their specific local and national laws.

Evidence suggests that hemp and cannabis may have been farmed for up to 12, years and had many uses including the making of cloth, rope, paper, food, and medicine.

However in the modern context, it was not until its introduction to American pharmacies by William Brooke O'Shaughnessy in that Cannabis extracts came into mainstream awareness as a medicine.

A wide range of cannabis extracts became easily available and could be gotten from travelling doctors and salesmen, doctors, and drugstores throughout America.

Food and Drug Administration Web site. Accessed May 7, Agriculture Improvement Act, S. Drug Enforcement Administration, Department of Justice.

Final order. Fed Regist. Abuse potential assessment of cannabidiol CBD in recreational polydrug users: A randomized, double-blind, controlled trial.

Epub Oct 2. Epub Jul Cannabidiol improves frequency and severity of seizures and reduces adverse events in an open-label add-on prospective study.

Epub Aug 9. Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test.

Braz J Psychiatry. Epub Oct The unexpected identification of the cannabimimetic, 5F-ADB, and dextromethorphan in commercially available cannabidiol e-liquids.

Forensic Sci Int. Epub Nov 1. Am J Psychiatry. N Engl J Med. J Nutr. Low-dose cannabidiol is safe but not effective in the treatment of Crohn's Disease, a randomized controlled trial.

Dig Dis Sci. Cannabidiol treatment for refractory seizures in Sturge-Weber Syndrome. Cannabidiol for the prevention of graft-versus-host-disease after allogeneic hematopoietic cell transplantation: results of a phase II study.

Biol Blood Marrow Transplant. Drug-drug interaction between clobazam and cannabidiol in children with refractory epilepsy.

Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial. Lancet Neurol. Efficacy and safety of cannabidiol and tetrahydrocannabivarin on glycemic and lipid parameters in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, parallel group pilot study.

Diabetes Care. Cannabidiol as a potential treatment for febrile infection-related epilepsy syndrome FIRES in the acute and chronic phases.

J Child Neurol. Cannabidiol as a new treatment for drug-resistant epilepsy in tuberous sclerosis complex. Interactions between cannabidiol and commonly used antiepileptic drugs.

Trial of cannabidiol for drug-resistant seizures in the Dravet Syndrome. Labeling accuracy of cannabidiol extracts sold online.

JAMA Nov; The non-psychoactive cannabis-constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis.

Analgesic and anti-inflammatory activity of constituents of Cannabis sativa L. Inflammation ; Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania.

J Psychopharmacol ; Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression.

Br J Pharmacol ; Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement.

Neurosci Lett ; Cannabidiol: a promising new drug for neurodegenerative disorders? CNS Neurosci Ther ; Bisogno T, Di Marzo Y.

The role of the endocannabinoid system in Alzheimer's disease: facts and hypotheses. Curr Pharm Des ; Zuardi AW. Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action.

Rev Bras Psiquiatr ; Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Trends Pharmacol Sci ; Booz GW. Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress.

Free Radic Biol Med ; Pickens JT. Sedative activity of cannabis in relation to its delta'-trans-tetrahydrocannabinol and cannabidiol content.

Monti JM. Hypnoticlike effects of cannabidiol in the rat. Psychopharmacology Berl ; Karler R, Turkanis SA. Subacute cannabinoid treatment: anticonvulsant activity and withdrawal excitability in mice.

The anticonvulsant activity of cannabidiol and cannabinol. Life Sci ; Anticonvulsant interaction of cannabidiol and ethosuximide in rats.

J Pharm Pharmacol ; Consroe P, Wolkin A. Cannabidiol-antiepilpetic drug comparisons and interactions in experimentally induced seizures in rats.

J Pharmacol Exp Ther ; Letter: Cannabidiol and Cannabis sativa extract protect mice and rats against convulsive agents. Assessing antidepressant activity in rodents: recent developments and future needs.

Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L. Pharmacol Biochem Behav ; Effects of intracisternal administration of cannabidiol on the cardiovascular and behavioral responses to acute restraint stress.

Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats. FEBS Lett ; Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis.

PLoS One ;6:e Modulation of mediotemporal and ventrostriatal function in humans by Delta9-tetrahydrocannabinol: a neural basis for the effects of Cannabis sativa on learning and psychosis.

Arch Gen Psychiatry ; Influence of cannabidiol on deltatetrahydrocannabinol effects. Clin Pharmacol Ther ; Cannabidiol increases Fos expression in the nucleus accumbens but not in the dorsal striatum.

Cannabidiol inhibits the hyperlocomotion induced by psychomimetic drugs in mice. Eur J Pharmacol ; Int J Neuropsychopharmacol ; Effects of cannabidiol in animal models predictive of antipsychotic activity.

Cannabidiol reverses the reduction in social interaction produced by low dose Delta-tetrahydrocannabinol in rats. Cannabidiol as a potential treatment for psychosis.

Eur Neuropsychopharmacol ; Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders.

Modulation of effective connectivity during emotional processing by Delta 9-tetrahydrocannabinol and cannabidiol. Cannabidiol inhibitory effect on marble-burying behavior: involvement of CB1 receptors.

Behav Pharmacol ; Anti-aversive effects of cannabidiol on innate fear-induced behaviors evoked by an ethological model of panic attacks based on a prey vs the wild snake Epicrates cenchria crassus confrontation paradigm.

Neuropsychopharmacology ; Behav Pharmacol ;S Effects of cannabidiol and diazepam on behavioral and cardiovascular responses induced by contextual conditioned fear in rats.

Behav Brain Res ; Anxiolytic-like effect of cannabidiol in the rat Vogel conflict test. Prog Neuropsychopharmacol Biol Psychiatry ; Pharmacological characterization of cannabinoids in the elevated plus maze.

Antianxiety effect of cannabidiol in the elevated plus-maze. Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation.

J Hepatol ; Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy.

J Am Coll Cardiol ; Cannabidiol protects retinal neurons by preserving glutamine synthetase activity in diabetes.

Mol Vis ; Neuroprotective and blood-retinal barrier-preserving effects of cannabidiol in experimental diabetes. Am J Pathol ; Cannabidiol attenuates high glucose-induces endothelial cell inflammatory response and barrier disruption.

Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type 1 diabetic peripheral neuropathic pain.

Mol Pain ; Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer.

J Mol Med Berl ; A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells. Int Immunopharmacol ; J Neurochem ; Cannabidiol, a non-psychoactive cannabinoid compound inhibits human glioma cell migration and invasiveness.

A combined preclinical therapy of cannabinoids and temozolomide against glioma. Mol Cancer Ther ; Serum-dependent effects of tamoxifen and cannabinoids upon C6 glioma cell viability.

Biochem Pharmacol ; Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy.

Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis. Breast Cancer Res Treat ; Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells.

Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma.

Cannabidiol as a potential anticancer drug. Br J Clin Pharmacol ; Cannabis with high cannabidiol content is associated with fewer psychotic experiences.

Schizophr Res ; Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment.

Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders.

Epilepsia ; Sativex long-term use: an open-label trial in patients with spasticity due to multiple sclerosis. J Neurol ; A placebo-controlled, parallel group, randomized withdrawal study of subjects with symptoms of spasticity due to multiple sclerosis who are receiving long-term Sativex nabiximols.

Mult Scler ; An open-label study of cannabis-based extracts for bladder dysfuntion in advanced multiple sclerosis. Randomized controlled trial of Sativex to treat detrusor overactivity in multiple sclerosis.

Long-term use of a cannabis-based treatment in spasticity and other symptoms in multiple sclerosis. Eur J Neurol ; GW Pharmaceuticals Web site.

Accessed: May 31, Natural Medicines Web site. Accessed May 31, Effects of ipsapirone and cannabidiol on human experimental anxiety.

J Psychopharmacol ;7 1 Suppl Long-retained metabolites of delta9- and delta8-tetrahydrocannabinols identified as novel fatty acid conjugates.

Res Commun Chem Pathol Pharmacol ; Pharmacokinetics of cannabidiol in dogs. Drug Metab Dispos ; In vivo cytogenetic effects of cannabinoids.

J Clin Psychopharmacol ; CBD For Epilepsy. CBD For Glaucoma. CBD For Inflammation. CBD For Nausea. CBD For Neuro-degeneration. CBD For Neuropathy.

CBD For Obesity. CBD For Rheumatism. CBD For Schizophrenia. CBD For Sleep. CBD For Stress. CBD For Strokes.

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